High-resolution, ultrasensitive and quantitative DNA double-strand break labeling in eukaryotic cells using i-BLESS

Anna Biernacka, Magdalena Skrzypczak, Yingjie Zhu, Philippe Pasero, Maga Rowicka, Krzysztof Ginalski

Published: 2020-12-20 DOI: 10.1038/s41596-020-00448-3

DNA double-strand breaks

i-BLESS

ultrasensitive detection

genome stability

qDSB-Seq

AI 解读

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DNA double-strand breaks (DSBs) are implicated in various physiological processes, such as class-switch recombination or crossing-over during meiosis, but also present a threat to genome stability. Extensive evidence shows that DSBs are a primary source o
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ACKNOWLEDGMENTS
ACKNOWLEDGMENTS

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High-resolution, ultrasensitive and quantitative DNA double-strand break labeling in eukaryotic cells using i-BLESS

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