Rotarod
Bryan Killinger, sdwalto, Jeffrey Kordower
Published: 2024-02-29 DOI: 10.17504/protocols.io.36wgq3xmolk5/v1
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Abstract
Rotarod protocol optimized for mice. This test is made to assess motor coordination and balance. The results should show lower latency to fall numbers for mice with motor impairments.
Steps
1.
Training : Each mouse was given a training session. Four 5 min trials, 5 mins apart.
2.
Test Period (1 hour later) : Each mouse was place inside the rotarod apparatus with increasing speed (4 rpm to 40 rpm in 300 secs). Latency to fall was recorded. (Digital rotarod recorded it automatically)
3.
Each mouse received two consecutive trials. Mean latency to fall was used for analysis.
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